PlainPharmaWatch

Companies with the Most Payment Transactions

Data currency: Figures are rendered from the processed CMS Open Payments release. See our methodology for source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.

Companies ranked by total number of individual payment transactions, the most frequent payers in healthcare.

Companies with the Most Payment Transactions: 100 entries ranked by transactions from CMS Open Payments Program Year 2024. ABBVIE INC. leads with 1,766,164, out of 13,435,716 total (average 134,357.16 per entry). Figures are company-reported under the Physician Payments Sunshine Act, not evidence of wrongdoing.

What This Ranking Tells Us

Transaction volume reveals a different dimension of pharmaceutical industry engagement than dollar amounts. Companies topping this list make millions of individual payments, mostly small, meals, beverages, and educational materials provided during physician interactions. A company with 5 million transactions at $15 average per transaction is engaging with physicians at a fundamentally different scale than a company making 1,000 payments averaging $100,000. High transaction volume indicates broad, frequent touchpoints with the physician community.

What the Data Shows

This ranking covers 100 entries from the CMS Open Payments Public Use Files for Program Year 2024. The top-ranked entry, ABBVIE INC., reports transactions of 1,766,164, while the lowest entry on the list reports 27,568 - a span that captures the full range of pharmaceutical-industry engagement within this category. The aggregate transactions across all 100 ranked entries sums to 13,435,716, and the average is 134,357.16 per entry. Large gaps between the top and bottom of a ranking are normal in Open Payments data: a small number of major pharmaceutical manufacturers, large academic medical centers, or prolific research physicians typically account for a disproportionate share of total reported transfers of value.

Concentration is a key signal in this dataset. The single top entry, ABBVIE INC., represents 13.1% of the transactions aggregated across this ranking. The top 10 entries together represent 46.1% of the total, a useful indicator of how concentrated activity is at the high end of the distribution. In pharmaceutical payment data, high concentration at the top typically reflects a handful of companies with very broad sales forces or extensive patented product portfolios, a few academic medical centers conducting the bulk of industry-sponsored clinical research, or specialist physicians earning royalties from widely-used medical devices they helped invent. A flatter distribution, by contrast, suggests that industry engagement is more evenly spread across the sector.

Every figure on this page is drawn directly from the CMS Open Payments Public Use Files, which pharmaceutical and medical device manufacturers are legally required to report under the Physician Payments Sunshine Act (Section 6002 of the Affordable Care Act). The data covers general payments, research payments, and physician ownership or investment interests. Readers can verify any individual physician or teaching hospital at openpaymentsdata.cms.gov, the official CMS search tool. This ranking surfaces reported financial relationships for transparency purposes only and does not constitute medical advice, a judgment about individual prescribing practices, or evidence of any ethical or legal violation by listed parties. Many large payments fund legitimate research, consulting, and education activities that benefit patient care.

# Name Transactions
1 ABBVIE INC. 1,766,164
2 AstraZeneca Pharmaceuticals LP 864,383
3 PFIZER INC. 606,504
4 Lilly USA, LLC 544,519
5 Novo Nordisk Inc 497,147
6 Amgen Inc. 479,804
7 Novartis Pharmaceuticals Corporation 418,352
8 GlaxoSmithKline, LLC. 361,110
9 Medtronic, Inc. 353,343
10 Abbott Laboratories 302,960
11 Janssen Biotech, Inc. 298,176
12 Boston Scientific Corporation 278,290
13 E.R. Squibb & Sons, L.L.C. 241,583
14 Merck Sharp & Dohme LLC 223,349
15 Boehringer Ingelheim Pharmaceuticals, Inc. 218,635
16 Takeda Pharmaceuticals U.S.A., Inc. 186,599
17 Otsuka America Pharmaceutical, Inc. 186,436
18 GENZYME CORPORATION 185,572
19 Janssen Pharmaceuticals, Inc 169,416
20 Stryker Corporation 169,396
21 Regeneron Healthcare Solutions, Inc. 169,362
22 Salix Pharmaceuticals, a division of Bausch Health US, LLC 161,040
23 Bayer Healthcare Pharmaceuticals Inc. 158,535
24 UCB, Inc. 154,034
25 Teva Pharmaceuticals USA, Inc. 148,378
26 Astellas Pharma US Inc 147,377
27 ITI, Inc. (d/b/a Intra-Cellular Therapies, Inc.) 146,137
28 INTUITIVE SURGICAL, INC. 126,597
29 Gilead Sciences, Inc. 121,377
30 Lundbeck LLC 111,317
31 Incyte Corporation 109,620
32 Exact Sciences Corporation 107,726
33 Sumitomo Pharma America, Inc. 106,116
34 Neurocrine Biosciences, Inc. 101,993
35 Alcon Vision LLC 94,278
36 Phathom Pharmaceuticals, Inc. 93,549
37 Dermavant Sciences, Inc. 89,827
38 Bausch & Lomb Americas Inc. 89,527
39 Alkermes, Inc. 85,487
40 SUN PHARMACEUTICAL INDUSTRIES INC. 80,737
41 Axsome Therapeutics, Inc. 80,352
42 ZOLL Services LLC (A/K/A ZOLL LifeCor Corp) 80,299
43 Corium, LLC 76,552
44 Edwards Lifesciences Corporation 75,191
45 Smith+Nephew, Inc. 72,133
46 Dentsply Sirona Inc 68,448
47 ViiV Healthcare Company 66,926
48 Daiichi Sankyo Inc. 66,466
49 Celgene Corporation 62,972
50 Supernus Pharmaceuticals, Inc. 61,817
51 Galderma Laboratories, L.P. 60,902
52 ABIOMED 58,187
53 Dexcom, Inc. 56,186
54 Genentech USA, Inc. 55,859
55 Align Technology, Inc. 55,647
56 Eisai Inc. 51,617
57 Inspire Medical Systems, Inc. 51,523
58 Inari Medical, Inc. 50,440
59 Arthrex, Inc. 50,254
60 Alexion Pharmaceuticals, Inc. 49,117
61 Arcutis Biotherapeutics, Inc. 48,335
62 JAZZ PHARMACEUTICALS INC. 47,413
63 Organon Llc 46,490
64 ZIMVIE INC. 45,687
65 IRONSHORE PHARMACEUTICALS INC. 45,512
66 Novo Nordisk AS 43,976
67 Ardelyx, Inc. 42,443
68 SANOFI-AVENTIS U.S. LLC 42,082
69 Janssen Research & Development, LLC 40,226
70 Vanda Pharmaceuticals Inc. 39,906
71 LEO Pharma Inc. 38,160
72 Mallinckrodt Hospital Products Inc. 38,015
73 Collegium Pharmaceutical, Inc. 36,875
74 Biogen, Inc. 36,731
75 Alnylam Pharmaceuticals Inc. 36,687
76 Regeneron Pharmaceuticals, Inc. 36,508
77 Genentech, Inc. 36,410
78 Straumann USA LLC 35,786
79 Philips North America LLC 35,552
80 DePuy Synthes Sales Inc. 35,060
81 Corcept Therapeutics 34,877
82 EMD Serono, Inc. 34,399
83 Zimmer Biomet Holdings, Inc. 34,372
84 Tarsus Pharmaceuticals, Inc. 34,141
85 CSL Behring 33,578
86 Medical Device Business Services, Inc. 33,334
87 AIMMUNE THERAPEUTICS, INC. 32,655
88 ModernaTX, Inc. 31,546
89 Actelion Pharmaceuticals US, Inc. 31,315
90 Nevro Corp. 31,030
91 CooperVision Inc. 30,123
92 ATRICURE, INC. 29,986
93 Indivior Inc. 29,843
94 Johnson & Johnson Vision Care, Inc. 29,585
95 Mylan Specialty L.P. 29,170
96 MAYNE PHARMA COMMERCIAL LLC 29,072
97 Biosense Webster, Inc. 28,932
98 Hologic Sales and Service, LLC 28,377
99 Xeris Pharmaceuticals, Inc. 28,319
100 Kiniksa Pharmaceuticals International, plc 27,568

Source: CMS Open Payments, Program Year 2024.

Frequently Asked Questions

Why do some companies have millions of transactions?

The majority of high-volume transactions are food and beverage payments, pharmaceutical sales representatives regularly bring meals to physician offices during detailing visits. A single lunch for a 5-person office is reported as 5 separate transactions. Companies with large sales forces covering many therapeutic areas accumulate millions of these small-value transactions annually.

Do small transactions matter?

Research suggests that even small gifts like meals can influence prescribing behavior. Studies published in JAMA Internal Medicine found that physicians who received a single industry-sponsored meal were more likely to prescribe the promoted drug compared to physicians who did not. The aggregate impact of millions of small interactions across the healthcare system is significant.

Source: CMS Open Payments Database Industry payments to physicians and teaching hospitals · 2024

How to read this leaderboard

This page is generated dynamically from the latest PlainPharmaWatch snapshot of the CMS Open Payments database. Each row reflects an entity's reported total within the selected ranking dimension, companies, states, physicians, or teaching hospitals, and is recomputed on every request so values track the underlying ETL output rather than a frozen build-time copy. CMS publishes the dataset annually, with corrected snapshots issued mid-cycle when Sunshine-Act disputes change a record set. Anywhere PlainPharmaWatch presents a payment total, the figure is reconcilable to the row-level entries in the source dataset published at openpaymentsdata.cms.gov.

The Physician Payments Sunshine Act, enacted as Section 6002 of the Affordable Care Act, requires applicable manufacturers (drug, device, biological, and medical-supply makers) and applicable group purchasing organizations to report transfers of value made to physicians and teaching hospitals. Reportable categories include consulting fees, food and beverage, travel and lodging, education, gifts, speaking compensation, charitable contributions, royalties or licenses, research-related payments, and ownership or investment interests. Some categories are excluded by statute, payments under specific de minimis thresholds, research-related transfers tied to active clinical trials, and certain product samples, and these exclusions explain why aggregate figures here do not match every alternative pharma-spending measure.

Interpreting rank changes

Rank movement between annual releases reflects two distinct phenomena. Real underlying shifts occur when a manufacturer launches a major product, exits a therapeutic area, restructures its commercial organization, or settles a Department of Justice investigation that alters its marketing approach. Reporting-level shifts occur when CMS revises submission guidelines, when applicable-manufacturer definitions change, or when a previously unreported subsidiary begins consolidated reporting. PlainPharmaWatch does not attempt to attribute rank changes to either cause, that requires looking at the underlying payment-category breakdown on each company's detail page, which itself links back to the raw CMS records.

For physicians ranked individually, year-over-year rank instability is the norm: an active clinical-trial principal investigator may receive the bulk of their reported payments in one program year and far less in adjacent years. A surgeon who licenses a successful medical device may show a sudden royalty-driven spike and then stable lower amounts thereafter. Teaching-hospital rankings tend to be more stable because they reflect institution-wide aggregates across many simultaneously active research programs.

Where to look next

Click any entity name to drill into its full per-entity detail page. Company detail pages decompose total payments by category (consulting, food, royalties, etc.) and show the top recipient physicians and teaching hospitals. State detail pages show payments split between physician and teaching-hospital recipients, plus per-physician averages and recipient counts. The methodology page documents ingestion, normalization, and known limitations end-to-end. For context on the Sunshine Act itself and how the Open Payments dataset compares to alternative pharmaceutical-spending measures (Centers for Medicare and Medicaid Services Open Payments Frequently Asked Questions, the U.S. Food and Drug Administration's drug-approval registers, and academic literature on payment-prescribing correlations), the guides section walks through the relevant regulatory background.

Every figure on PlainPharmaWatch is rendered directly from federal source data, no number is typed in by an editor. This page draws directly on federal source data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-07-25.